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WHI3 mRNA-binding protein WHI3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855524, updated on 5-Sep-2021

Summary

Gene symbol
WHI3
Gene description
mRNA-binding protein WHI3
Primary source
SGD:S000005141
Locus tag
YNL197C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See WHI3 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (267608..269593, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene NADHX epimerase Neighboring gene Gcr2p Neighboring gene Slz1p Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA-binding protein WHI3
NP_014202.1
  • RNA binding protein that modulates mRNA stability; regulates genes involved in the cell cycle, sister chromatid cohesion, and the stress response; modulates the stability and translational efficiency of the CLN3 mRNA; colocalizes with P-bodies/stress granules where it may sequester specific mRNAs; regulates cell fate and the critical cell size required for passage through Start; Tpk1p-mediated phosphorylation inhibits Whi3p function, decreasing its interaction with CLN3 mRNA; regulates ploidy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    267608..269593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183035.1NP_014202.1  TPA: mRNA-binding protein WHI3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34761
    Conserved Domains (2) summary
    COG0724
    Location:450648
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12245
    Location:536624
    RRM_scw1_like; RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins
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