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ADE12 adenylosuccinate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855501, updated on 11-Apr-2024

Summary

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Gene symbol
ADE12
Gene description
adenylosuccinate synthase
Primary source
SGD:S000005164
Locus tag
YNL220W
See related
AllianceGenome:SGD:S000005164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BRA9
Summary
Enables DNA replication origin binding activity and adenylosuccinate synthase activity. Involved in purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to human ADSS1 (adenylosuccinate synthase 1) and ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (234413..235714)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribonuclease P/MRP protein subunit POP1 Neighboring gene dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase Neighboring gene ssDNA-dependent ATPase MGS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. STR2: a structure to string approach for locating G-box riboswitch shapes in pre-selected genes. Bergig O, et al. In Silico Biol, 2004. PMID 15752075
  2. Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein. Lipps G, et al. Biochem J, 1999 Aug 1. PMID 10417315, Free PMC Article
  3. Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties. Ryzhova TA, et al. Biochemistry (Mosc), 1998 Jun. PMID 9668204
  4. [Genetic control of metabolism of a mutagenic analog of 6-N-hydroxylaminopurine bases in Saccharomyces cerevisiae yeasts]. Koz'min SG, et al. Genetika, 1997 May. PMID 9273315
  5. Homology modeling of adenylosuccinate synthetase from Saccharomyces cerevisiae reveals a possible binding region for single-stranded ARS sequences. Sticht H, et al. J Biomol Struct Dyn, 1997 Jun. PMID 9195336

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylosuccinate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylosuccinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylosuccinate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' AMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylosuccinate synthase
NP_014179.1
  • Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    234413..235714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183058.1 → NP_014179.1  TPA: adenylosuccinate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014179.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZRM0, C7GPD7, D6W0X0, P80210
    UniProtKB/TrEMBL
    A0A6A5Q887, G2WLP3, N1NZ63
    Conserved Domains (1) summary
    pfam00709
    Location:4 → 428
    Adenylsucc_synt; Adenylosuccinate synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80210.3

Gene LinkOut

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