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CDC14B cell division cycle 14B [ Homo sapiens (human) ]

Gene ID: 8555, updated on 12-Sep-2021

Summary

Official Symbol
CDC14Bprovided by HGNC
Official Full Name
cell division cycle 14Bprovided by HGNC
Primary source
HGNC:HGNC:1719
See related
Ensembl:ENSG00000081377 MIM:603505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
Summary
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See CDC14B in Genome Data Viewer
Location:
9q22.32-q22.33
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (96492743..96619843, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99262390..99382125, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 367 Neighboring gene NSA2 pseudogene 7 Neighboring gene hyaluronan binding protein 4 Neighboring gene uncharacterized LOC105376163 Neighboring gene peroxiredoxin like 2C Neighboring gene makorin ring finger protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase CDC14B
Names
CDC14 cell division cycle 14 homolog B
NP_001070649.1
NP_001338496.1
NP_001338497.1
NP_001338498.1
NP_001338499.1
NP_003662.1
NP_201588.1
XP_011517449.2
XP_011517450.2
XP_011517451.2
XP_011517453.2
XP_011517454.2
XP_011517455.2
XP_011517458.2
XP_011517461.2
XP_016870729.2
XP_016870730.2
XP_016870731.1
XP_016870733.1
XP_016870734.1
XP_016870736.1
XP_016870737.1
XP_016870738.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077181.3NP_001070649.1  dual specificity protein phosphatase CDC14B isoform 3

    See identical proteins and their annotated locations for NP_001070649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 2, resulting in a protein (isoform 3) that has an alternate N-terminus, compared to isoform 2.
    Source sequence(s)
    AK126388, AL133477, BQ004840
    Consensus CDS
    CCDS43853.1
    UniProtKB/Swiss-Prot
    O60729
    Related
    ENSP00000364390.3, ENST00000375242.7
    Conserved Domains (2) summary
    pfam14671
    Location:15152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:209323
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001351567.3NP_001338496.1  dual specificity protein phosphatase CDC14B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AF064104, AI921238, AL353578, BF979799, EF611343
    Consensus CDS
    CCDS87662.1
    Related
    ENSP00000420572.1, ENST00000463569.5
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  3. NM_001351568.3NP_001338497.1  dual specificity protein phosphatase CDC14B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AI921238, BF979799, DB089608, EF611343
    Conserved Domains (2) summary
    cd14499
    Location:162335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:11153
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  4. NM_001351569.2NP_001338498.1  dual specificity protein phosphatase CDC14B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK126388, AL133477, BP272794, BQ004840, DA943563
    Conserved Domains (2) summary
    cd14499
    Location:162335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:11153
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  5. NM_001351570.1NP_001338499.1  dual specificity protein phosphatase CDC14B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK126388, AL133477, BG709497, BP272794, BQ004840, DB089608
    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. NM_003671.5NP_003662.1  dual specificity protein phosphatase CDC14B isoform 1

    See identical proteins and their annotated locations for NP_003662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment in the C-terminal region, compared to isoform 2.
    Source sequence(s)
    AF064104, AL133477, AL353578, BQ004840
    Consensus CDS
    CCDS6721.1
    UniProtKB/Swiss-Prot
    O60729
    Related
    ENSP00000364388.3, ENST00000375240.7
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  7. NM_033331.4NP_201588.1  dual specificity protein phosphatase CDC14B isoform 2

    See identical proteins and their annotated locations for NP_201588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AF064104, AL133477, AL353578, BQ004840
    Consensus CDS
    CCDS6722.1
    UniProtKB/Swiss-Prot
    O60729
    Related
    ENSP00000364389.1, ENST00000375241.6
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RNA

  1. NR_147239.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF064104, AK225361, AL133477, AL353578, BQ004840

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    96492743..96619843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519152.3XP_011517454.2  dual specificity protein phosphatase CDC14B isoform X6

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_011519147.3XP_011517449.2  dual specificity protein phosphatase CDC14B isoform X2

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_011519149.3XP_011517451.2  dual specificity protein phosphatase CDC14B isoform X4

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. XM_017015242.2XP_016870731.1  dual specificity protein phosphatase CDC14B isoform X9

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  5. XM_017015248.2XP_016870737.1  dual specificity protein phosphatase CDC14B isoform X15

  6. XM_011519156.3XP_011517458.2  dual specificity protein phosphatase CDC14B isoform X10

  7. XM_017015241.2XP_016870730.2  dual specificity protein phosphatase CDC14B isoform X8

    Conserved Domains (2) summary
    pfam14671
    Location:29117
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:154268
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. XM_017015247.2XP_016870736.1  dual specificity protein phosphatase CDC14B isoform X14

  9. XM_017015244.2XP_016870733.1  dual specificity protein phosphatase CDC14B isoform X11

  10. XM_011519153.3XP_011517455.2  dual specificity protein phosphatase CDC14B isoform X7

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  11. XM_011519148.3XP_011517450.2  dual specificity protein phosphatase CDC14B isoform X3

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  12. XM_017015240.2XP_016870729.2  dual specificity protein phosphatase CDC14B isoform X1

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  13. XM_011519159.3XP_011517461.2  dual specificity protein phosphatase CDC14B isoform X16

  14. XM_017015249.1XP_016870738.1  dual specificity protein phosphatase CDC14B isoform X17

  15. XM_017015245.1XP_016870734.1  dual specificity protein phosphatase CDC14B isoform X12

  16. XM_011519151.3XP_011517453.2  dual specificity protein phosphatase CDC14B isoform X5

    Conserved Domains (2) summary
    pfam14671
    Location:29166
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:223337
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_929864.3 RNA Sequence

  2. XR_929865.3 RNA Sequence

  3. XR_002956814.1 RNA Sequence

  4. XR_001746407.1 RNA Sequence

  5. XR_001746408.1 RNA Sequence

  6. XR_001746409.2 RNA Sequence

  7. XR_001746406.2 RNA Sequence

  8. XR_929868.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033332.1: Suppressed sequence

    Description
    NM_033332.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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