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NAR1 iron-sulfur cluster assembly protein NAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855481, updated on 13-Apr-2024

Summary

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Gene symbol
NAR1
Gene description
iron-sulfur cluster assembly protein NAR1
Primary source
SGD:S000005184
Locus tag
YNL240C
See related
AllianceGenome:SGD:S000005184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and ferredoxin hydrogenase activity. Involved in iron-sulfur cluster assembly. Located in cytosol and membrane. Orthologous to several human genes including CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (198502..199977, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Atg2p Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene bleomycin hydrolase Neighboring gene kexin KEX2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPR monitored redox titration of the cofactors of Saccharomyces cerevisiae Nar1. Hagedoorn PL, et al. J Vis Exp, 2014 Nov 26. PMID 25490157, Free PMC Article
  2. Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1. Urzica E, et al. Biochemistry, 2009 Jun 9. PMID 19385603
  3. Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis. Balk J, et al. Biochem Soc Trans, 2005 Feb. PMID 15667273
  4. Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Zhao W, et al. Mech Ageing Dev, 2014 Jun. PMID 24486555
  5. The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins. Balk J, et al. EMBO J, 2004 May 19. PMID 15103330, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A deletion of NAR1 caused a similar increased sensitivity to oxygen.
    Title: [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode.
  2. Nar1 holds two iron-sulfur (Fe/S) clusters at conserved amino- and carboxyl-terminal cysteine motifs, both of which are essential for Nar1 function and cell viability.
    Title: Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1.
  3. Results suggest that Nar1p represents a crucial, novel component of the emerging cytosolic iron/sulfur protein assembly machinery that catalyses an essential and ancient process in eukaryotes.
    Title: The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables ferredoxin hydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
iron-sulfur cluster assembly protein NAR1
NP_014159.1
  • Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    198502..199977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183078.1 → NP_014159.1  TPA: iron-sulfur cluster assembly protein NAR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014159.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0V3, P23503
    UniProtKB/TrEMBL
    A0A6V8SAX2, B3LP79, B5VQG9, C7GPC0, N1NY14
    Conserved Domains (1) summary
    COG4624
    Location:21 → 484
    Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23503.2

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