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SLA2 Sla2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855478, updated on 14-Sep-2021

Summary

Gene symbol
SLA2
Gene description
Sla2p
Primary source
SGD:S000005187
Locus tag
YNL243W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END4; MOP2
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Genomic context

See SLA2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (188051..190957)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Vps75p Neighboring gene U2-type spliceosomal complex subunit CWC25 Neighboring gene translation initiation factor eIF1 Neighboring gene Atg2p Neighboring gene glucose-6-phosphate dehydrogenase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
 
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cortical patch assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bipolar cellular bud site selection TAS
Traceable Author Statement
more info
PubMed 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in fungal-type cell wall organization TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cellular bud neck HDA PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of incipient cellular bud site IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mating projection tip HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Sla2p
NP_014156.2
  • Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    188051..190957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183081.2NP_014156.2  TPA: Sla2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014156.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P33338
    Conserved Domains (3) summary
    smart00307
    Location:763965
    ILWEQ; I/LWEQ domain
    COG1196
    Location:420546
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:7269
    ANTH; ANTH domain
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