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RAD50 MRX complex DNA-binding subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 855471, updated on 5-Oct-2021

Summary

Gene symbol
RAD50
Gene description
MRX complex DNA-binding subunit
Primary source
SGD:S000005194
Locus tag
YNL250W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See RAD50 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (175410..179348)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL17/YmL30 Neighboring gene Nrd1 complex RNA-binding subunit Neighboring gene Mpa43p Neighboring gene DNA-directed RNA polymerase I subunit RPA49

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables G-quadruplex DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance via recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
 
part_of Mre11 complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MRX complex DNA-binding subunit
NP_014149.1
  • Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    175410..179348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183088.1NP_014149.1  TPA: MRX complex DNA-binding subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12753
    Conserved Domains (1) summary
    TIGR00606
    Location:21302
    rad50
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