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DSL1 Dsl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855463, updated on 23-Jul-2026
Official Symbol
DSL1
Official Full Name
Dsl1p
Primary source
SGD:S000005202
Locus tag
YNL258C
See related
AllianceGenome:SGD:S000005202; FungiDB:YNL258C; VEuPathDB:YNL258C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RNS1
Summary
Involved in ER-dependent peroxisome organization and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum and nucleus. Part of Dsl1/NZR complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See DSL1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (158109..160373, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein LTO1 Neighboring gene copper metallochaperone ATX1 Neighboring gene Sip3p Neighboring gene trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. Travis SM, et al. J Biol Chem, 2020 Jul 24. PMID 32409579, Free PMC Article
  2. Tip20p reaches out to Dsl1p to tether membranes. Munson M. Nat Struct Mol Biol, 2009 Feb. PMID 19190660, Free PMC Article
  3. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534429, Free PMC Article
  4. Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. McFaline-Figueroa JR, et al. Aging Cell, 2011 Oct. PMID 21726403, Free PMC Article
  5. Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. Ishikawa T, et al. J Gen Appl Microbiol, 2005 Apr. PMID 15942868

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNARE-mediated homotypic ER fusion requires DSL1.
    Title: ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway.
  2. subunits of the Dsl1 complex (Dsl1, Dsl3, and Tip20), as well as the SNAREs Ufe1 and Sec20, are ER-resident proteins that do not seem to move into COPII vesicles.
    Title: The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation.
  3. a direct role of the Dsl1 complex, in particular Tip20p, in the formation and stabilization of ER SNARE complexes.
    Title: The Dsl1 tethering complex actively participates in soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (SNARE) complex assembly at the endoplasmic reticulum in Saccharomyces cerevisiae.
  4. Studies indicate that Dsl1 tethering complex seems to be designed to expose an unstructured domain of Dsl1p at its top, which is required to capture vesicles.
    Title: Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules.
  5. Study determined the structure of the Dsl1 complex, revealing a tower containing at its base the binding sites for two endoplasmic reticulum SNAREs and at its tip a flexible lasso for capturing vesicles.
    Title: A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.
  6. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly
    Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
  7. Crystal structures show 2 of the 3 subunits, Tip20p and Dsl1p, resemble known subunits of the exocyst complex, establishing a structural connection among tethering complexes and implying that many of their subunits are derived from a common progenitor.
    Title: Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.
  8. DSL1 is required for the stable interaction of the SNARE Use1p with a central subcomplex consisting of Tip20p and the SNARE proteins Ufe1p and Sec20p.
    Title: Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables kinetochore adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ER-dependent peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Dsl1/NZR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsl1/NZR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Dsl1/NZR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Dsl1p
NP_014141.1
  • Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    158109..160373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183096.1 → NP_014141.1  Dsl1p

    See identical proteins and their annotated locations for NP_014141.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0T5, P53847
    UniProtKB/TrEMBL
    B3LPA1
    Conserved Domains (2) summary
    pfam11989
    Location:560 → 753
    Dsl1_C; Retrograde transport protein Dsl1 C terminal
    pfam11988
    Location:6 → 360
    Dsl1_N; Retrograde transport protein Dsl1 N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53847.1

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