U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BNI1 formin BNI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855450, updated on 9-Dec-2024

Summary

Official Symbol
BNI1
Official Full Name
formin BNI1
Primary source
SGD:S000005215
Locus tag
YNL271C
See related
AllianceGenome:SGD:S000005215; FungiDB:YNL271C; VEuPathDB:YNL271C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PPF3; SHE5
Summary
Enables profilin binding activity. Involved in several processes, including barbed-end actin filament capping; budding cell apical bud growth; and cytoskeleton organization. Located in several cellular components, including actin filament; cellular bud tip; and incipient cellular bud site. Part of polarisome. Is active in cytosol and mating projection tip. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1; autosomal dominant nonsyndromic deafness 1; primary ovarian insufficiency; primary ovarian insufficiency 2A; and sensorineural hearing loss. Orthologous to several human genes including DIAPH2 (diaphanous related formin 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BNI1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (129522..135383, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Tof1p Neighboring gene guanine nucleotide exchange factor SEC2 Neighboring gene arginine permease ALP1 Neighboring gene Bsc4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables profilin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables profilin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament bundle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in budding cell apical bud growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in budding cell apical bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular hyperosmotic response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in formin-nucleated actin cable assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in formin-nucleated actin cable assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell division site IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell division site IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular bud neck IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cellular bud tip IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
PubMed 
located_in mating projection tip HDA PubMed 
is_active_in mating projection tip IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitotic actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of polarisome IDA
Inferred from Direct Assay
more info
PubMed 
part_of polarisome IPI
Inferred from Physical Interaction
more info
PubMed 
located_in prospore membrane HDA PubMed 

General protein information

Preferred Names
formin BNI1
NP_014128.2
  • Formin; polarisome component; nucleates the formation of linear actin filaments, involved in budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; some functional redundancy with BNR1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    129522..135383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183109.2NP_014128.2  TPA: formin BNI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014128.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0S3, O13450, P41832
    UniProtKB/TrEMBL
    B3LPB0, C7GP92, C8ZFW8
    Conserved Domains (5) summary
    PTZ00121
    Location:17391841
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:703979
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06367
    Location:511707
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:13481741
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:178458
    Drf_GBD; Diaphanous GTPase-binding Domain