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TOF1 Tof1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855448, updated on 5-Sep-2021

Summary

Gene symbol
TOF1
Gene description
Tof1p
Primary source
SGD:S000005217
Locus tag
YNL273W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See TOF1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (122883..126599)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Bor1p Neighboring gene glyoxylate reductase Neighboring gene guanine nucleotide exchange factor SEC2 Neighboring gene formin BNI1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TOF1 gene: The TOF1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in replication fork arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in replication fork protection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in replication fork protection IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of replication fork protection complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Tof1p
NP_014126.1
  • Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    122883..126599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183111.1NP_014126.1  TPA: Tof1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53840
    Conserved Domains (1) summary
    pfam04821
    Location:45366
    TIMELESS; Timeless protein
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