U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CAF40 CCR4-NOT core subunit CAF40 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855428, updated on 19-Nov-2025
Official Symbol
CAF40
Official Full Name
CCR4-NOT core subunit CAF40
Primary source
SGD:S000005232
Locus tag
YNL288W
See related
AllianceGenome:SGD:S000005232; FungiDB:YNL288W; VEuPathDB:YNL288W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in positive regulation of transcription elongation by RNA polymerase II. Part of CCR4-NOT core complex. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See CAF40 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (90303..91424)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pcl1p Neighboring gene ncRNA Neighboring gene coatomer subunit gamma Neighboring gene U2 snRNP complex subunit CUS2

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. Russell P, et al. J Mol Biol, 2002 Sep 6. PMID 12215412
  2. Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes. Cui Y, et al. Mol Genet Genomics, 2008 Apr. PMID 18214544
  3. Ccr4-Not and TFIIS Function Cooperatively To Rescue Arrested RNA Polymerase II. Dutta A, et al. Mol Cell Biol, 2015 Jun 1. PMID 25776559, Free PMC Article
  4. Insights into the structure of the CCR4-NOT complex by electron microscopy. Nasertorabi F, et al. FEBS Lett, 2011 Jul 21. PMID 21669201, Free PMC Article
  5. Specific roles for the Ccr4-Not complex subunits in expression of the genome. Azzouz N, et al. RNA, 2009 Mar. PMID 19155328, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
CCR4-NOT core subunit CAF40
NP_014111.1
  • Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    90303..91424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183126.1 → NP_014111.1  TPA: CCR4-NOT core subunit CAF40

    See identical proteins and their annotated locations for NP_014111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Q5, P53829
    UniProtKB/TrEMBL
    A6ZSJ0, B3LPC6, B5VQC9, C7GS51, C8ZGN3, N1NYB3
    Conserved Domains (1) summary
    COG5209
    Location:30 → 373
    RCD1; Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53829.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools