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PUS4 pseudouridine synthase PUS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855424, updated on 11-Aug-2022

Summary

Gene symbol
PUS4
Gene description
pseudouridine synthase PUS4
Primary source
SGD:S000005236
Locus tag
YNL292W
See related
AllianceGenome:SGD:S000005236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis and tRNA modification. Located in mitochondrion and nucleus. Orthologous to several human genes including TRUB1 (TruB pseudouridine synthase family member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PUS4 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (82806..84017)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rim21p Neighboring gene Rab GTPase-activating protein MSB3 Neighboring gene Mid1p Neighboring gene replication factor C subunit 3

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PUS4 gene: The PUS4 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables tRNA pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
pseudouridine synthase PUS4
NP_014107.1
  • Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    82806..84017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183130.1NP_014107.1  TPA: pseudouridine synthase PUS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Q1, P48567
    UniProtKB/TrEMBL
    A0A0L8VI58, A0A816APX1, A0A8H4BWA1, A6ZSI6, B3LPD0, B5VQC5, C7GS55, N1P4W9
    Conserved Domains (1) summary
    cd02867
    Location:3331
    PseudoU_synth_TruB_4; Pseudouridine synthase homolog 4