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MON2 Mon2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855420, updated on 7-Jun-2026
Official Symbol
MON2
Official Full Name
Mon2p
Primary source
SGD:S000005241
Locus tag
YNL297C
See related
AllianceGenome:SGD:S000005241; FungiDB:YNL297C; VEuPathDB:YNL297C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YSL2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in endocytosis; protein targeting to vacuole; and retrograde transport, endosome to Golgi. Located in early endosome membrane and trans-Golgi network. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See MON2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (71673..76583, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene non-canonical poly(A) polymerase TRF5 Neighboring gene serine/threonine protein kinase CLA4 Neighboring gene Mrx6p Neighboring gene Rim21p

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Jochum A, et al. Mol Cell Biol, 2002 Jul. PMID 12052896, Free PMC Article
  2. Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system. Wicky S, et al. Mol Cell Biol, 2004 Sep. PMID 15314152, Free PMC Article
  3. Dopey proteins are essential but overlooked regulators of membrane trafficking. Molière A, et al. J Cell Sci, 2022 Apr 1. PMID 35388894
  4. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. Efe JA, et al. J Cell Sci, 2005 Oct 15. PMID 16219684
  5. Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Barbosa S, et al. Traffic, 2010 Aug. PMID 20477991

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L].
    Title: Mon2 is a negative regulator of the monomeric G protein, Arl1.
  2. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
    Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
  3. Ysl2p represents an essential, evolutionarily conserved member of a network controlling direct binding and membrane docking of Ggas..
    Title: Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.
  4. Mon2p is a scaffold protein with novel conserved domains, and is involved in multiple aspects of endomembrane trafficking.
    Title: Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
  5. Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1
    Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trans-Golgi network membrane organization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Mon2p
NP_014102.1
  • Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    71673..76583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183135.1 → NP_014102.1  Mon2p

    See identical proteins and their annotated locations for NP_014102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P7, P48563
    UniProtKB/TrEMBL
    A6ZSI2, B5VQC1, C7GS58, N1NZQ9
    Conserved Domains (3) summary
    pfam16206
    Location:936 → 1161
    Mon2_C; C-terminal region of Mon2 protein
    pfam12783
    Location:202 → 362
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16213
    Location:8 → 176
    DCB; dimerization and cyclophilin-binding domain of Mon2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48563.1

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