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EMW1 tetratricopeptide repeat-containing protein EMW1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855403, updated on 3-Jun-2026
Official Symbol
EMW1
Official Full Name
tetratricopeptide repeat-containing protein EMW1
Primary source
SGD:S000005257
Locus tag
YNL313C
See related
AllianceGenome:SGD:S000005257; FungiDB:YNL313C; VEuPathDB:YNL313C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fungal-type cell wall organization. Located in cytoplasm and nucleus. Orthologous to human TTC27 (tetratricopeptide repeat domain 27). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See EMW1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (45308..48022, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Atp11p Neighboring gene Dal82p Neighboring gene Rfa2p Neighboring gene putative SCF ubiquitin ligase complex subunit SKP2

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Emw1p/YNL313cp is essential for maintenance of the cell wall in Saccharomyces cerevisiae. Sipling T, et al. Microbiology (Reading), 2011 Apr. PMID 21273246
  2. Generation of Saccharomyces cerevisiae deletants and basic phenotypic analysis of eight novel genes from the left arm of chromosome XIV. Maftahi M, et al. Yeast, 1998 Feb. PMID 9544246
  3. Emw1/TTC27 is a chaperone required for folding of the eukaryotic elongation factor 2. Yang M, et al. Cell Mol Life Sci, 2026 Mar 10. PMID 41806041, Free PMC Article
  4. Identification of new proteins related with cisplatin resistance in Saccharomyces cerevisiae. Burgos-Molina AM, et al. Appl Microbiol Biotechnol, 2021 Mar. PMID 33576883
  5. Comprehensive analysis of genes involved in the oxidative stress tolerance using yeast heterozygous deletion collection. Okada N, et al. FEMS Yeast Res, 2014 May. PMID 24410772

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables translation elongation factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' protein folding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tetratricopeptide repeat-containing protein EMW1
NP_014086.1
  • Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    45308..48022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183151.1 → NP_014086.1  tetratricopeptide repeat-containing protein EMW1

    See identical proteins and their annotated locations for NP_014086.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0N2, P42842
    UniProtKB/TrEMBL
    G2WLF6, N1NXU2
    Conserved Domains (2) summary
    COG0457
    Location:500 → 723
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:596 → 631
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42842.1

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