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VNX1 calcium/hydrogen antiporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 855395, updated on 7-Jun-2026
Official Symbol
VNX1
Official Full Name
calcium/hydrogen antiporter
Primary source
SGD:S000005265
Locus tag
YNL321W
See related
AllianceGenome:SGD:S000005265; FungiDB:YNL321W; VEuPathDB:YNL321W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables calcium:proton antiporter activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Involved in potassium ion transport; proton transmembrane transport; and sodium ion transport. Located in endoplasmic reticulum membrane; fungal-type vacuole membrane; and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See VNX1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (34696..37422)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Lem3p Neighboring gene Kre1p Neighboring gene uncharacterized protein Neighboring gene Hxt14p

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional characterization of a wheat NHX antiporter gene TaNHX2 that encodes a K(+)/H(+) exchanger. Xu Y, et al. PLoS One, 2013. PMID 24223765, Free PMC Article
  2. Paradigm for industrial strain improvement identifies sodium acetate tolerance loci in Zymomonas mobilis and Saccharomyces cerevisiae. Yang S, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20484677, Free PMC Article
  3. Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae. Cagnac O, et al. J Biol Chem, 2007 Aug 17. PMID 17588950
  4. Roles for intracellular cation transporters in respiratory growth of yeast. Zhang F, et al. Metallomics, 2019 Oct 16. PMID 31402362
  5. Subcellular potassium and sodium distribution in Saccharomyces cerevisiae wild-type and vacuolar mutants. Herrera R, et al. Biochem J, 2013 Sep 15. PMID 23829444

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the relative importance of Nhx1p, Vnx1p, and Vcx1p in the vacuolar accumulation of monovalent cations
    Title: Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae.
  2. the vacuole-bound Vnx1p appears to play roles in the regulation of ion homeostasis and cellular pH
    Title: Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
calcium/hydrogen antiporter
NP_014078.1
  • Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    34696..37422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183159.1 → NP_014078.1  calcium/hydrogen antiporter

    See identical proteins and their annotated locations for NP_014078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0M5, P42839
    UniProtKB/TrEMBL
    A6ZSG0, C8ZGK4, N1P437
    Conserved Domains (2) summary
    COG0387
    Location:490 → 904
    ChaA; Ca2+/H+ antiporter [Inorganic ion transport and metabolism]
    pfam03733
    Location:239 → 296
    YccF; Inner membrane component domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42839.1

Gene LinkOut

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