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THI12 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855384, updated on 8-Jun-2019

Summary

Gene symbol
THI12
Gene description
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Primary source
SGD:S000005276
Locus tag
YNL332W
Gene type
protein coding
RNA name
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See THI12 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (14832..15854)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ2 Neighboring gene putative aryl-alcohol dehydrogenase Neighboring gene histone deacetylase RPD3

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
thiamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
NP_014067.1
  • Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    14832..15854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183170.1NP_014067.1  TPA: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014067.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42883
    Conserved Domains (2) summary
    cd13650
    Location:5255
    PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily
    pfam09084
    Location:16238
    NMT1; NMT1/THI5 like
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