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PRE5 proteasome core particle subunit alpha 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855362, updated on 17-May-2024

Summary

Gene symbol
PRE5
Gene description
proteasome core particle subunit alpha 6
Primary source
FungiDB:YMR314W
Locus tag
YMR314W
See related
SGD:S000004931; AllianceGenome:SGD:S000004931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Used to study cancer. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PRE5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (901709..902413)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Elongator subunit ELP6 Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome core particle subunit alpha 6
NP_014045.1
  • Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    901709..902413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182825.1NP_014045.1  TPA: proteasome core particle subunit alpha 6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0E1, P40302
    UniProtKB/TrEMBL
    A0A6A5PTH4, A6ZN31, B3LMK2, B5VQ80, C7GPU9, C8ZFI5, G2WL23, N1P645
    Conserved Domains (1) summary
    cl00467
    Location:6217
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...