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NIP1 translation initiation factor eIF3 core subunit c [ Saccharomyces cerevisiae S288C ]

Gene ID: 855357, updated on 30-Jul-2025
Official Symbol
NIP1
Official Full Name
translation initiation factor eIF3 core subunit c
Primary source
SGD:S000004926
Locus tag
YMR309C
See related
AllianceGenome:SGD:S000004926; FungiDB:YMR309C; VEuPathDB:YMR309C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables translation initiation factor activity and translation initiation factor binding activity. Involved in translational initiation. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex and multi-eIF complex. Orthologous to human EIF3C (eukaryotic translation initiation factor 3 subunit C) and EIF3CL (eukaryotic translation initiation factor 3 subunit C like). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See NIP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (892988..895426, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene importin PSE1 Neighboring gene putative methyltransferase Neighboring gene PP1-complex regulatory subunit GLC8

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. NIP1, a gene required for nuclear transport in yeast. Gu Z, et al. Proc Natl Acad Sci U S A, 1992 Nov 1. PMID 1332047, Free PMC Article
  2. Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes. Khoshnevis S, et al. Nucleic Acids Res, 2014 Apr. PMID 24423867, Free PMC Article
  3. Nip1p associates with 40 S ribosomes and the Prt1p subunit of eukaryotic initiation factor 3 and is required for efficient translation initiation. Greenberg JR, et al. J Biol Chem, 1998 Sep 4. PMID 9722586
  4. Formyl-methionine-mediated eukaryotic ribosome quality control pathway for cold adaptation. Lee CS, et al. Mol Cell, 2025 Feb 6. PMID 39721582
  5. Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. Karásková M, et al. J Biol Chem, 2012 Aug 17. PMID 22718758, Free PMC Article

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binding of eIF1 to the c/Nip1-NTD is equally important for its initial recruitment to PICs and for its proper functioning in selecting the translational start site
    Title: Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition.
  2. the NIP1-N-terminal domain is required for efficient assembly of preinitiation complexes and also regulates the selection of AUG start codons in vivo
    Title: Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of multi-eIF complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
translation initiation factor eIF3 core subunit c
NP_014040.1
  • eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; eIF3 is also involved in programmed stop codon readthrough

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    892988..895426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182820.1 → NP_014040.1  TPA: translation initiation factor eIF3 core subunit c

    See identical proteins and their annotated locations for NP_014040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZN26, D6W0D6, P32497
    UniProtKB/TrEMBL
    B3LMJ7, N1NXU3
    Conserved Domains (2) summary
    smart00088
    Location:712 → 796
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:92 → 640
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32497.2

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