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PSE1 Pse1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855356, updated on 18-Jan-2023

Summary

Gene symbol
PSE1
Gene description
Pse1p
Primary source
SGD:S000004925
Locus tag
YMR308C
See related
AllianceGenome:SGD:S000004925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAP121
Summary
Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in nucleocytoplasmic transport; regulation of mitotic nuclear division; and regulation of protein desumoylation. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to several human genes including IPO5 (importin 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PSE1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (888952..892221, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative 1,3-beta-D-glucan synthase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene translation initiation factor eIF3 core subunit c Neighboring gene putative methyltransferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PSE1 gene: The PSE1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nuclear import signal receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein desumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein desumoylation IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Pse1p
NP_014039.1
  • Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; required for stability of the Dam1p-Duo1p complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    888952..892221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182819.1NP_014039.1  TPA: Pse1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014039.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0D5, P32337
    UniProtKB/TrEMBL
    A0A6A5PTX3, C7GPV5, G2WL17, N1NYW3
    Conserved Domains (6) summary
    sd00044
    Location:106128
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:396435
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:403475
    HEAT_2; HEAT repeats
    pfam18808
    Location:274365
    Importin_rep_4; Importin repeat
    pfam18816
    Location:10011054
    Importin_rep_5; Importin repeat
    pfam18829
    Location:766868
    Importin_rep_6; Importin repeat 6