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HSH155 U2 snRNP complex subunit HSH155 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855332, updated on 4-Feb-2026
Official Symbol
HSH155
Official Full Name
U2 snRNP complex subunit HSH155
Primary source
SGD:S000004901
Locus tag
YMR288W
See related
AllianceGenome:SGD:S000004901; FungiDB:YMR288W; VEuPathDB:YMR288W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in spliceosomal complex assembly. Part of U2 snRNP and U2-type prespliceosome. Used to study acute myeloid leukemia; bladder urothelial carcinoma; myelodysplastic syndrome; and uterine corpus endometrial carcinoma. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See HSH155 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (845571..848486)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein uL30m MRPL33 Neighboring gene exoribonuclease II Neighboring gene aminodeoxychorismate lyase ABZ2 Neighboring gene ATP-dependent RNA helicase HAS1

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Chemical Inhibition of Pre-mRNA Splicing in Living Saccharomyces cerevisiae. Hansen SR, et al. Cell Chem Biol, 2019 Mar 21. PMID 30639260, Free PMC Article
  2. SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing. Tang Q, et al. Genes Dev, 2016 Dec 15. PMID 28087715, Free PMC Article
  3. Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress. Mathew V, et al. J Cell Biol, 2017 Dec 4. PMID 28978642, Free PMC Article
  4. Functional analysis of Hsh155/SF3b1 interactions with the U2 snRNA/branch site duplex. Carrocci TJ, et al. RNA, 2018 Aug. PMID 29752352, Free PMC Article
  5. Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Pauling MH, et al. Mol Cell Biol, 2000 Mar. PMID 10688664, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast.
    Title: Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast.
  2. Results show the identification of a potential UHM-ULM protein domains interaction between Cus2 and Hsh155. Amino acid substitutions in the ULM of Hsh155 abolish the binding in vivo.
    Title: Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction.
  3. Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.
    Title: Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.
  4. different HSH155 alleles elicit disparate effects on splicing: some increase the fidelity of BS selection while others decrease fidelity. Our data support a model wherein conformational changes in SF3b1 promote U2 association with the BS independently of the action of the DEAD-box ATPase Prp5. We propose that SF3b1 functions to stabilize weak U2/BS duplexes to drive spliceosome assembly and splicing
    Title: SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast.
  5. show here that hsh155 mutant alleles in Saccharomyces cerevisiae, counterparts of SF3B1 mutations frequently found in cancers, specifically change splicing of suboptimal BS pre-mRNA substrates
    Title: SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in U2-type prespliceosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
U2 snRNP complex subunit HSH155
NP_014015.1
  • U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    845571..848486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182795.1 → NP_014015.1  U2 snRNP complex subunit HSH155

    See identical proteins and their annotated locations for NP_014015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0B5, P49955
    UniProtKB/TrEMBL
    G2WKZ7, N1NZ66
    Conserved Domains (2) summary
    COG5181
    Location:1 → 971
    HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
    sd00044
    Location:519 → 543
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49955.1

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