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SCS7 fatty acid alpha-hydroxylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855315, updated on 18-Jan-2023

Summary

Gene symbol
SCS7
Gene description
fatty acid alpha-hydroxylase
Primary source
SGD:S000004885
Locus tag
YMR272C
See related
AllianceGenome:SGD:S000004885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FAH1
Summary
Enables fatty acid alpha-hydroxylase activity and sphingosine hydroxylase activity. Involved in inositol phosphoceramide metabolic process and very long-chain fatty acid metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SCS7 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (809623..810777, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene orotate phosphoribosyltransferase URA10 Neighboring gene tRNA-Gln Neighboring gene uncharacterized protein Neighboring gene Zds1p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SCS7 gene: The SCS7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables fatty acid alpha-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid alpha-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid alpha-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables sphingosine hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol phosphoceramide metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inositol phosphoceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in very long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane ISM
Inferred from Sequence Model
more info
PubMed 

General protein information

Preferred Names
fatty acid alpha-hydroxylase
NP_013999.1
  • Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    809623..810777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182779.1NP_013999.1  TPA: fatty acid alpha-hydroxylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013999.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W098, Q03529
    UniProtKB/TrEMBL
    A0A0L8VJ82, A0A6A5PTC6, A6ZMY7, B3LMF9, C7GTM8, C8ZFD7, G2WKY0, H0GLG7, N1NXQ7
    Conserved Domains (2) summary
    COG5274
    Location:31224
    CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
    cl01132
    Location:149380
    FA_hydroxylase; Fatty acid hydroxylase superfamily