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GFD1 Gfd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855297, updated on 19-Nov-2025
Official Symbol
GFD1
Official Full Name
Gfd1p
Primary source
SGD:S000004868
Locus tag
YMR255W
See related
AllianceGenome:SGD:S000004868; FungiDB:YMR255W; VEuPathDB:YMR255W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA export from nucleus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See GFD1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (778001..778567)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VII Neighboring gene Pet111p

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Study of a region on yeast chromosome XIII that complements pet G199 mutants (COX7) and carries a new non-essential gene. Nobrega MP, et al. Braz J Med Biol Res, 1998 Mar. PMID 9698782
  2. Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export. Zheng C, et al. J Biol Chem, 2010 Jul 2. PMID 20463024, Free PMC Article
  3. Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2. Grant RP, et al. J Mol Biol, 2008 Feb 29. PMID 18190927, Free PMC Article
  4. Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function. Suntharalingam M, et al. J Biol Chem, 2004 Aug 20. PMID 15208322
  5. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. Hodge CA, et al. EMBO J, 1999 Oct 15. PMID 10523319, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gfd1 serves as a bridging factor between Gle1 and Nab2-bound mRNA during export
    Title: Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Gfd1p
NP_013982.1
  • Coiled-coiled hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    778001..778567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182762.1 → NP_013982.1  TPA: Gfd1p

    See identical proteins and their annotated locations for NP_013982.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W081, Q04839
    UniProtKB/TrEMBL
    A6ZMX0, B3LME3, B5VQ21, C7GR97, C8ZFC1, N1P5X7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04839.1

Gene LinkOut

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