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ZRC1 Zn(2+) transporter ZRC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855284, updated on 14-Nov-2024

Summary

Official Symbol
ZRC1
Official Full Name
Zn(2+) transporter ZRC1
Primary source
SGD:S000004856
Locus tag
YMR243C
See related
AllianceGenome:SGD:S000004856; FungiDB:YMR243C; VEuPathDB:YMR243C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OSR1
Summary
Enables zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ZRC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (754838..756166, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L20A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Coa6p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in inorganic ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Zn(2+) transporter ZRC1
NP_013970.1
  • Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    754838..756166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182750.1NP_013970.1  TPA: Zn(2+) transporter ZRC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013970.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W070, P20107
    UniProtKB/TrEMBL
    A6ZMV7, B3LMD2, C7GRA8, C8ZFA9, N1NXN3
    Conserved Domains (1) summary
    COG1230
    Location:6375
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]