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RNH1 RNA-DNA hybrid ribonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 855274, updated on 2-Nov-2024

Summary

Official Symbol
RNH1
Official Full Name
RNA-DNA hybrid ribonuclease
Primary source
SGD:S000004847
Locus tag
YMR234W
See related
AllianceGenome:SGD:S000004847; FungiDB:YMR234W; VEuPathDB:YMR234W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA-DNA hybrid ribonuclease activity. Involved in RNA catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See RNH1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (740266..741312)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Fus2p Neighboring gene Tri1p Neighboring gene GTPase-activating protein RNA1 Neighboring gene chromatin modification protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA-DNA hybrid ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA-DNA hybrid ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-DNA hybrid ribonuclease
NP_013961.1
  • Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    740266..741312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182741.1NP_013961.1  TPA: RNA-DNA hybrid ribonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013961.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W060, Q04740
    UniProtKB/TrEMBL
    A6ZMU7, B3LMC3, B5VQ02, C8ZF99, G2WKU2, N1NXM4
    Conserved Domains (2) summary
    COG3341
    Location:1180
    Rnh1; RNase HI-related protein, contains viroplasmin and RNaseH domains [General function prediction only]
    cd09280
    Location:190345
    RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts