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PEP5 tethering complex subunit PEP5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855271, updated on 5-Sep-2021

Summary

Gene symbol
PEP5
Gene description
tethering complex subunit PEP5
Primary source
SGD:S000004844
Locus tag
YMR231W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END1; VAM1; VPL9; VPS11; VPT11
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Genomic context

See PEP5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (733545..736634)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10B Neighboring gene uncharacterized protein Neighboring gene Fus2p Neighboring gene Tri1p

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in late endosome to vacuole transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in organelle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle tethering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CORVET complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of HOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of HOPS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tethering complex subunit PEP5
NP_013958.1
  • Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    733545..736634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182738.1NP_013958.1  TPA: tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12868
    Conserved Domains (3) summary
    cd00162
    Location:928972
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    pfam12451
    Location:9761021
    VPS11_C; Vacuolar protein sorting protein 11 C terminal
    cl17238
    Location:928975
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
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