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MRE11 MRX complex nuclease subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 855264, updated on 5-Sep-2021

Summary

Gene symbol
MRE11
Gene description
MRX complex nuclease subunit
Primary source
SGD:S000004837
Locus tag
YMR224C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NGS1; RAD58; XRS4
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Genomic context

See MRE11 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (718575..720653, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative serine hydrolase Neighboring gene ubiquitin-specific protease UBP8 Neighboring gene mitochondrial 54S ribosomal protein YmL44 Neighboring gene oxidoreductase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MRE11 gene: The MRE11 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3'-5'-exodeoxyribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endodeoxyribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing involved in repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic DNA double-strand break formation TAS
Traceable Author Statement
more info
PubMed 
involved_in meiotic DNA double-strand break processing TAS
Traceable Author Statement
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription involved in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
 
part_of Mre11 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MRX complex nuclease subunit
NP_013951.1
  • Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    718575..720653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182731.1NP_013951.1  TPA: MRX complex nuclease subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32829
    Conserved Domains (1) summary
    TIGR00583
    Location:6413
    mre11; DNA repair protein (mre11)
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