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FSH2 putative serine hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855262, updated on 8-Mar-2025

Summary

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Official Symbol
FSH2
Official Full Name
putative serine hydrolase
Primary source
SGD:S000004835
Locus tag
YMR222C
See related
AllianceGenome:SGD:S000004835; FungiDB:YMR222C; VEuPathDB:YMR222C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity. Located in cytoplasm. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See FSH2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (715638..716309, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene Fmp42p Neighboring gene ubiquitin-specific protease UBP8 Neighboring gene MRX complex nuclease subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-Throughput Screening of an Octanoic Acid Producer Strain Library Enables Detection of New Targets for Increasing Titers in Saccharomyces cerevisiae. Baumann L, et al. ACS Synth Biol, 2021 May 21. PMID 33979526
  2. FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. Gowsalya R, et al. FEMS Yeast Res, 2019 May 1. PMID 30776074
  3. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Baxter SM, et al. Mol Cell Proteomics, 2004 Mar. PMID 14645503
  4. TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele. Milgrom E, et al. Genetics, 2005 Nov. PMID 16118188, Free PMC Article
  5. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative serine hydrolase
NP_013949.1
  • Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    715638..716309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182729.1 → NP_013949.1  TPA: putative serine hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013949.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W047, Q05015
    UniProtKB/TrEMBL
    B3LMB0, B5VPZ1, C8ZF86
    Conserved Domains (1) summary
    pfam03959
    Location:1 → 214
    FSH1; Serine hydrolase (FSH1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05015.1

Gene LinkOut

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