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ERG2 C-8 sterol isomerase ERG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855242, updated on 6-Sep-2021

Summary

Gene symbol
ERG2
Gene description
C-8 sterol isomerase ERG2
Primary source
SGD:S000004815
Locus tag
YMR202W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END11
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Genomic context

See ERG2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (667537..668205)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD14 Neighboring gene ncRNA Neighboring gene Tom40p Neighboring gene Inp1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ERG2 gene: The ERG2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables C-8 sterol isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IC
Inferred by Curator
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-8 sterol isomerase ERG2
NP_013929.1
  • C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    667537..668205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182709.1NP_013929.1  TPA: C-8 sterol isomerase ERG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013929.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32352
    Conserved Domains (1) summary
    pfam04622
    Location:15216
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
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