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VTI1 v-SNARE protein VTI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855237, updated on 15-Mar-2026
Official Symbol
VTI1
Official Full Name
v-SNARE protein VTI1
Primary source
SGD:S000004810
Locus tag
YMR197C
See related
AllianceGenome:SGD:S000004810; FungiDB:YMR197C; VEuPathDB:YMR197C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNAP receptor activity. Involved in Golgi vesicle transport; macroautophagy; and organelle fusion. Located in Golgi membrane. Part of SNARE complex. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See VTI1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (658545..659198, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Icy1p Neighboring gene uncharacterized protein Neighboring gene Cik1p Neighboring gene cyclin CLN1

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. Bryant NJ, et al. J Cell Biol, 1998 Aug 10. PMID 9700156, Free PMC Article
  2. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Wang J, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746902, Free PMC Article
  3. TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi. Stein IS, et al. Biochem J, 2009 Apr 1. PMID 19076069
  4. Structures of yeast vesicle trafficking proteins. Tishgarten T, et al. Protein Sci, 1999 Nov. PMID 10595551, Free PMC Article
  5. N-terminal domain of vacuolar SNARE Vam7p promotes trans-SNARE complex assembly. Xu H, et al. Proc Natl Acad Sci U S A, 2012 Oct 30. PMID 23071309, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.
    Title: Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.
  2. Lipid-anchored Vti1 was fully active, and lipid-anchored Nyv1 permitted the reaction to proceed up to hemifusion, and lipid-anchored Vam3 interfered already before hemifusion.
    Title: Vacuolar SNARE protein transmembrane domains serve as nonspecific membrane anchors with unequal roles in lipid mixing.
  3. Data show that TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi.
    Title: TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi vesicle fusion to target membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in amphisome-lysosome fusion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vacuolar calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in autophagosome membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
v-SNARE protein VTI1
NP_013924.1
  • Golgi membrane protein and Qb class v-SNARE; involved in cis-Golgi membrane traffic; interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; human homolog VTI1A can complement the yeast null mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    658545..659198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182704.1 → NP_013924.1  v-SNARE protein VTI1

    See identical proteins and their annotated locations for NP_013924.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W022, Q04338
    UniProtKB/TrEMBL
    A6ZMQ9, B3LM85, C7GRF4, C8ZF62, G2WKQ3, N1NYK8
    Conserved Domains (2) summary
    cd15862
    Location:127 → 185
    SNARE_Vti1; SNARE motif of Vti1
    pfam05008
    Location:12 → 92
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04338.3

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