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FPY1 flavin adenine dinucleotide pyrophosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855216, updated on 11-Jul-2026
Official Symbol
FPY1
Official Full Name
flavin adenine dinucleotide pyrophosphatase
Primary source
SGD:S000004790
Locus tag
YMR178W
See related
AllianceGenome:SGD:S000004790; FungiDB:YMR178W; VEuPathDB:YMR178W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables FAD diphosphatase activity. Involved in flavin-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See FPY1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (618479..619303)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ecm5p Neighboring gene Mmt1p Neighboring gene Spt21p Neighboring gene polynucleotide 5'-phosphatase

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae. Lynch JH, et al. PLoS One, 2018. PMID 29902190, Free PMC Article
  2. The Pof1 nicotinamide mononucleotide adenylyl transferase has a non-canonical role in NAD(+) metabolism in the budding yeast Saccharomyces cerevisiae. Lee YC, et al. J Biol Chem, 2026 Jun. PMID 41999890, Free PMC Article
  3. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
  4. A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition. Barkova A, et al. Mob DNA, 2022 Nov 18. PMID 36401307, Free PMC Article
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FAD diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH pyrophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in flavin-containing compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flavin-containing compound metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
flavin adenine dinucleotide pyrophosphatase
NP_013903.1
  • FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    618479..619303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182684.1 → NP_013903.1  flavin adenine dinucleotide pyrophosphatase

    See identical proteins and their annotated locations for NP_013903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W001, Q03219
    UniProtKB/TrEMBL
    B3LM64
    Conserved Domains (1) summary
    COG1058
    Location:3 → 265
    CinA; Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03219.1

Gene LinkOut

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