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SIP18 Sip18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855213, updated on 8-Mar-2025

Summary

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Official Symbol
SIP18
Official Full Name
Sip18p
Primary source
SGD:S000004787
Locus tag
YMR175W
See related
AllianceGenome:SGD:S000004787; FungiDB:YMR175W; VEuPathDB:YMR175W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid binding activity. Involved in cellular response to water deprivation. Located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See SIP18 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (611016..611255)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA damage-responsive protein 48 Neighboring gene Pai3p Neighboring gene uncharacterized protein Neighboring gene Ecm5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of SIP18 at the beginning of rehydration was shown to be due to high transcription of the gene during the drying process.
    Title: Expression of GPD1 and SIP18 genes during rehydration in active dry industrial Saccharomyces cerevisiae cider-making yeast strains (ADY).
  2. SIP18p acts as an inhibitor of apoptosis in yeast under dehydration stress, suggested by its antioxidative capacity through the reduction of ROS accumulation after an H2O2 attack.
    Title: Sip18 hydrophilin prevents yeast cell death during desiccation stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sip18p
NP_013900.1
  • Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    611016..611255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182681.1 → NP_013900.1  TPA: Sip18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZZ7, P50263
    UniProtKB/TrEMBL
    A6ZMN4, B3LM61, C7GTS6, C8ZF37, G2WKM8, N1NYI8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50263.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
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