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MLH1 mismatch repair ATPase MLH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855203, updated on 5-Aug-2018

Summary

Gene symbol
MLH1
Gene description
mismatch repair ATPase MLH1
Primary source
SGD:S000004777
Locus tag
YMR167W
Gene type
protein coding
RNA name
mismatch repair ATPase MLH1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PMS2

Genomic context

See MLH1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (594886..597195)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene phosphatidate phosphatase PAH1 Neighboring gene Mme1p Neighboring gene Cep3p Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD3

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to DNA insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to bubble DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to heteroduplex DNA loop binding IDA
Inferred from Direct Assay
more info
PubMed 
mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
meiotic heteroduplex formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutLalpha complex IPI
Inferred from Physical Interaction
more info
PubMed 
MutLbeta complex IPI
Inferred from Physical Interaction
more info
PubMed 
MutLgamma complex IPI
Inferred from Physical Interaction
more info
PubMed 
chiasma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm HDA PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
nucleus HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mismatch repair ATPase MLH1
NP_013890.1
  • Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    594886..597195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182671.1NP_013890.1  TPA: mismatch repair ATPase MLH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013890.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38920
    Conserved Domains (4) summary
    COG0323
    Location:1744
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    cd03483
    Location:208335
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:508769
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:23127
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
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