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SWP1 dolichyl-diphosphooligosaccharide-protein glycotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855180, updated on 3-Jun-2026
Official Symbol
SWP1
Official Full Name
dolichyl-diphosphooligosaccharide-protein glycotransferase
Primary source
SGD:S000004757
Locus tag
YMR149W
See related
AllianceGenome:SGD:S000004757; FungiDB:YMR149W; VEuPathDB:YMR149W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. Is active in endoplasmic reticulum membrane. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SWP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (560996..561856)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 subunit i Neighboring gene Ldo45p Neighboring gene Ldo16p Neighboring gene endopeptidase catalytic subunit IMP1 Neighboring gene Yim1p

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sulfhydryl modification of the yeast Wbp1p inhibits oligosaccharyl transferase activity. Pathak R, et al. Biochemistry, 1995 Apr 4. PMID 7703229
  2. Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyl transferase activity. te Heesen S, et al. EMBO J, 1993 Jan. PMID 8428586, Free PMC Article
  3. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. Silberstein S, et al. J Cell Biol, 1995 Oct. PMID 7593165, Free PMC Article
  4. The alpha subunit of the Saccharomyces cerevisiae oligosaccharyltransferase complex is essential for vegetative growth of yeast and is homologous to mammalian ribophorin I. Silberstein S, et al. J Cell Biol, 1995 Feb. PMID 7860628, Free PMC Article
  5. Heterologous expression and biophysical characterization of soluble oligosaccharyl transferase subunits. Dempski RE Jr, et al. Arch Biochem Biophys, 2004 Nov 1. PMID 15464727

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
dolichyl-diphosphooligosaccharide-protein glycotransferase
NP_013869.1
  • Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    560996..561856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182651.1 → NP_013869.1  dolichyl-diphosphooligosaccharide-protein glycotransferase

    See identical proteins and their annotated locations for NP_013869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZX1, Q02795
    UniProtKB/TrEMBL
    A6ZMK8, G2WKK0
    Conserved Domains (2) summary
    PRK09401
    Location:83 → 163
    PRK09401; reverse gyrase; Reviewed
    pfam05817
    Location:156 → 282
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02795.1

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