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SAS2 histone acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855157, updated on 14-Nov-2024

Summary

Official Symbol
SAS2
Official Full Name
histone acetyltransferase
Primary source
SGD:S000004734
Locus tag
YMR127C
See related
AllianceGenome:SGD:S000004734; FungiDB:YMR127C; VEuPathDB:YMR127C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAT8
Summary
Enables histone acetyltransferase activity. Involved in silent mating-type cassette heterochromatin formation and subtelomeric heterochromatin formation. Located in chromatin. Part of SAS acetyltransferase complex. Orthologous to human KAT7 (lysine acetyltransferase 7) and KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See SAS2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (522329..523345, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sto1p Neighboring gene Dlt1p Neighboring gene ATP-dependent RNA helicase ECM16 Neighboring gene Pom152p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AK9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BK12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K122 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K14 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K18 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K23 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K27 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K36 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K56 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K16 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H4K16 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K8 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide-lysine-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAS acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAS acetyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone acetyltransferase
NP_013846.1
  • Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    522329..523345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182628.1NP_013846.1  TPA: histone acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013846.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZV0, P40963
    UniProtKB/TrEMBL
    B3LM18, C7GU91, C8ZEY2, G2WKH8, N1NXD5
    Conserved Domains (1) summary
    COG5027
    Location:31338
    SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]