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ASC1 guanine nucleotide-binding protein subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 855143, updated on 5-Sep-2021

Summary

Gene symbol
ASC1
Gene description
guanine nucleotide-binding protein subunit beta
Primary source
SGD:S000004722
Locus tag
YMR116C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ASU9; CPC2; NAD1
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Genomic context

See ASC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (499456..500688, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative peptide hydrolase Neighboring gene Mgr3p Neighboring gene ncRNA Neighboring gene kinetochore-associated Ndc80 complex subunit SPC24 Neighboring gene protein SHH3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ASC1 gene: The ASC1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose mediated signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translational frameshifting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nonfunctional rRNA decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta
NP_013834.1
  • G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    499456..500688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182616.1NP_013834.1  TPA: guanine nucleotide-binding protein subunit beta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38011
    Conserved Domains (2) summary
    cd00200
    Location:9314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2063
    7WD40; WD40 repeat [structural motif]
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