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MGR3 Mgr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855142, updated on 30-Jul-2025
Official Symbol
MGR3
Official Full Name
Mgr3p
Primary source
SGD:S000004721
Locus tag
YMR115W
See related
AllianceGenome:SGD:S000004721; FungiDB:YMR115W; VEuPathDB:YMR115W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FMP24
Summary
Enables misfolded protein binding activity. Involved in mitochondrial protein quality control. Located in mitochondrial inner membrane. Part of i-AAA complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See MGR3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (497704..499209)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dihydrofolate synthase Neighboring gene putative peptide hydrolase Neighboring gene 40S ribosomal protein RACK1 ASC1 Neighboring gene ncRNA Neighboring gene kinetochore-associated Ndc80 complex subunit SPC24

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. Wu X, et al. J Cell Biol, 2018 Jan 2. PMID 29138251, Free PMC Article
  2. Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Schreiner B, et al. Mol Biol Cell, 2012 Nov. PMID 22993211, Free PMC Article
  3. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2008 Dec. PMID 18843051, Free PMC Article
  4. Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18. Fiumera HL, et al. Genetics, 2009 Jun. PMID 19307606, Free PMC Article
  5. Barth syndrome mutations that cause tafazzin complex lability. Claypool SM, et al. J Cell Biol, 2011 Feb 7. PMID 21300850, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial protein quality control IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into mitochondrial intermembrane space NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of i-AAA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of i-AAA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of i-AAA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Mgr3p
NP_013833.1
  • Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    497704..499209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182615.1 → NP_013833.1  TPA: Mgr3p

    See identical proteins and their annotated locations for NP_013833.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT8, Q04472
    UniProtKB/TrEMBL
    G2WKG5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04472.1

Gene LinkOut

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