PGM2 phosphoglucomutase PGM2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PGM2
Official Full Name: phosphoglucomutase PGM2
Primary source: SGD:S000004711
Locus tag: YMR105C
See related: AllianceGenome:SGD:S000004711; FungiDB:YMR105C; VEuPathDB:YMR105C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAL5
Summary: Enables phosphoglucomutase activity. Involved in several processes, including UDP-alpha-D-glucose metabolic process; carbohydrate biosynthetic process; and glucose 1-phosphate metabolic process. Located in cytoplasm. Used to study congenital disorder of glycosylation It. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to several human genes including PGM5 (phosphoglucomutase 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See PGM2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (475897..477606, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
Title: Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
The overexpression of both SNR84 and PGM2 increased the transcriptional levels of GAL and regulatory genes; however, the transcriptional levels of these genes were lower than those in S. cerevisiae adapted to high galactose concentrations.
Title: Enhancement of bioethanol production from Gracilaria verrucosa by Saccharomyces cerevisiae through the overexpression of SNR84 and PGM2.
Based on the above results we suggest that YMR278w encodes phosphoglucomutase and not phosphoribomutase.
Title: Molecular characterization reveals that YMR278w encoded protein is environmental stress response homologue of Saccharomyces cerevisiae PGM2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables intramolecular phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoglucomutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoglucomutase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglucomutase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphoglucomutase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoglucomutase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-alpha-D-glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-alpha-D-glucose metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactose catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in galactose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 1-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 1-phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose 1-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphoglucomutase PGM2

NP_013823.1

EC 5.4.2.2

Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

475897..477606 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182605.1 → NP_013823.1 TPA: phosphoglucomutase PGM2

See identical proteins and their annotated locations for NP_013823.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZS7, P37012

UniProtKB/TrEMBL

A6ZMG1, B3LLZ5, B5VPN1, C7GVE1, C8ZEV7, G2WKF2, N1NYS4

Conserved Domains (1) summary

cd03085
Location:6 → 569

PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...