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LAF1 Laf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855128, updated on 15-Mar-2026
Official Symbol
LAF1
Official Full Name
Laf1p
Primary source
SGD:S000004708
Locus tag
YMR102C
See related
AllianceGenome:SGD:S000004708; FungiDB:YMR102C; VEuPathDB:YMR102C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Acts upstream of or within sterol transport. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See LAF1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (469848..472352, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene MYND-type zinc finger protein MUB1 Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK2

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Anderson JB, et al. Genetics, 2003 Apr. PMID 12702675, Free PMC Article
  2. TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae. Topolska M, et al. Biomolecules, 2020 Nov 25. PMID 33255682, Free PMC Article
  3. Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. Murley A, et al. J Cell Biol, 2017 Sep 4. PMID 28774891, Free PMC Article
  4. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
  5. Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway. Kritsiligkou P, et al. J Biol Chem, 2021 Jan-Jun. PMID 33894203, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the beta-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae.
    Title: TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within sterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
Laf1p
NP_013820.1
  • Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    469848..472352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182602.1 → NP_013820.1  Laf1p

    See identical proteins and their annotated locations for NP_013820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZS5, Q03138, Q03177, Q04435
    UniProtKB/TrEMBL
    A6ZMF9, B3LLZ3, B5VPN0, G2WKF0, N1NYC8
    Conserved Domains (2) summary
    sd00039
    Location:176 → 221
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:173 → 506
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03177.1

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