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VPS20 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855101, updated on 11-Sep-2024

Summary

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Official Symbol
VPS20
Primary source
SGD:S000004682
Locus tag
YMR077C
See related
AllianceGenome:SGD:S000004682; FungiDB:YMR077C; VEuPathDB:YMR077C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CHM6; VPL10; VPT20
Summary
Involved in ATP export; intralumenal vesicle formation; and late endosome to vacuole transport. Located in endoplasmic reticulum. Part of ESCRT III complex. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (421484..422149, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pds5p Neighboring gene tRNA-Val Neighboring gene Ctf18p Neighboring gene phosphatidylinositol/phosphatidylcholine transfer protein SEC14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional reconstitution of ESCRT-III assembly and disassembly. Saksena S, et al. Cell, 2009 Jan 9. PMID 19135892, Free PMC Article
  2. The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Pineda-Molina E, et al. Traffic, 2006 Aug. PMID 16749904
  3. Regulation of yeast ESCRT-III membrane scission activity by the Doa4 ubiquitin hydrolase. Johnson N, et al. Mol Biol Cell, 2017 Mar 1. PMID 28057764, Free PMC Article
  4. Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. Yeo SC, et al. J Cell Sci, 2003 Oct 1. PMID 12953057
  5. Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast. Kojima R, et al. J Mol Biol, 2016 Jun 5. PMID 27075672

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of Vps20 to the Doa4 N-terminus inhibits a non-catalytic function of Doa4 that promotes ILV formation.
    Title: Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intralumenal vesicle formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intralumenal vesicle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IEA
Inferred from Electronic Annotation
more info
  
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT III complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ESCRT-III subunit protein VPS20
NP_013794.1
  • Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    421484..422149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182576.1 → NP_013794.1  TPA: ESCRT-III subunit protein VPS20 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013794.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZQ1, Q04272
    UniProtKB/TrEMBL
    A6ZMD6, B3LLX0, B5VPK3, C7GL47, C8ZET0, G2WKC5, N1P095
    Conserved Domains (1) summary
    pfam03357
    Location:15 → 186
    Snf7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04272.3

Gene LinkOut

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