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RCO1 Rco1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855097, updated on 7-Jun-2026
Official Symbol
RCO1
Official Full Name
Rco1p
Primary source
SGD:S000004680
Locus tag
YMR075W
See related
AllianceGenome:SGD:S000004680; FungiDB:YMR075W; VEuPathDB:YMR075W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable zinc ion binding activity. Involved in regulation of nucleobase-containing compound metabolic process and transcription elongation by RNA polymerase II. Located in nucleus. Part of Rpd3S complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RCO1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (413982..416036)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Irc21p Neighboring gene Sdd2p Neighboring gene uncharacterized protein Neighboring gene sister chromatid cohesion factor PDS5 Neighboring gene tRNA-Val

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S. Xu C, et al. Structure, 2008 Nov 12. PMID 18818090, Free PMC Article
  2. Gene loops enhance transcriptional directionality. Tan-Wong SM, et al. Science, 2012 Nov 2. PMID 23019609, Free PMC Article
  3. Antisense transcription-dependent chromatin signature modulates sense transcript dynamics. Brown T, et al. Mol Syst Biol, 2018 Feb 12. PMID 29440389, Free PMC Article
  4. Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Li B, et al. Science, 2007 May 18. PMID 17510366
  5. Nascent transcript sequencing visualizes transcription at nucleotide resolution. Churchman LS, et al. Nature, 2011 Jan 20. PMID 21248844, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional dissection of Rco1 revealed that besides its known chromatin-recognition interfaces, other regions of Rco1 are also critical for Rpd3S to recognize nucleosomes.
    Title: Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex.
  2. The association of Rpd3S with chromatin requires its Eaf3 subunit, which binds histone H3 methylated at lysine 36.
    Title: Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of antisense RNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3S complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3S complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3S complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
Rco1p
NP_013791.1
  • Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    413982..416036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182574.1 → NP_013791.1  Rco1p

    See identical proteins and their annotated locations for NP_013791.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZP9, Q04779
    UniProtKB/TrEMBL
    A0ABF7PIS6, B3LLW8, C8ZES7, N1P5G6
    Conserved Domains (2) summary
    cd15534
    Location:416 → 469
    PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
    cd15535
    Location:262 → 306
    PHD1_Rco1; PHD finger 1 found in Saccharomyces cerevisiae transcriptional regulatory protein Rco1 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04779.1

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