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MBD3L1 methyl-CpG binding domain protein 3 like 1 [ Homo sapiens (human) ]

Gene ID: 85509, updated on 11-Sep-2019

Summary

Official Symbol
MBD3L1provided by HGNC
Official Full Name
methyl-CpG binding domain protein 3 like 1provided by HGNC
Primary source
HGNC:HGNC:15774
See related
Ensembl:ENSG00000170948 MIM:607963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBD3L
Summary
This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See MBD3L1 in Genome Data Viewer
Location:
19p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8842593..8843340)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8943074..8954016)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily Z member 1 Neighboring gene zinc finger protein 558 Neighboring gene mucin 16, cell surface associated Neighboring gene bolA family member 3 pseudogene 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138263, MGC138269

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
methylation-dependent chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
methyl-CpG-binding domain protein 3-like 1
Names
MBD3-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145208.2NP_660209.2  methyl-CpG-binding domain protein 3-like 1

    See identical proteins and their annotated locations for NP_660209.2

    Status: REVIEWED

    Source sequence(s)
    AC008734, BC112064
    Consensus CDS
    CCDS12209.1
    UniProtKB/Swiss-Prot
    Q8WWY6
    Related
    ENSP00000304198.2, ENST00000305625.2
    Conserved Domains (2) summary
    pfam14048
    Location:81172
    MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
    pfam16564
    Location:1076
    MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8842593..8843340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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