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CCS1 copper chaperone CCS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855054, updated on 6-Sep-2021

Summary

Gene symbol
CCS1
Gene description
copper chaperone CCS1
Primary source
SGD:S000004641
Locus tag
YMR038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LYS7
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Genomic context

See CCS1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (347511..348260, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative tyrosine protein phosphatase MIH1 Neighboring gene stress-responsive transcriptional activator MSN2 Neighboring gene chromatin-binding transcription coactivator SUB1 Neighboring gene Yet2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CCS1 gene: The CCS1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide dismutase copper chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide dismutase copper chaperone activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables superoxide dismutase copper chaperone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in protein maturation by copper ion transfer IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
copper chaperone CCS1
NP_013752.1
  • Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    347511..348260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182535.1NP_013752.1  TPA: copper chaperone CCS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013752.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40202
    Conserved Domains (1) summary
    PLN02957
    Location:15238
    PLN02957; copper, zinc superoxide dismutase
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