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UNG1 uracil-DNA glycosylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854987, updated on 9-Sep-2018

Summary

Gene symbol
UNG1
Gene description
uracil-DNA glycosylase
Primary source
SGD:S000004483
Locus tag
YML021C
Gene type
protein coding
RNA name
uracil-DNA glycosylase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See UNG1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (229734..230813, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Smc5-Smc6 complex subunit NSE5 Neighboring gene adenine phosphoribosyltransferase APT1 Neighboring gene hypothetical protein Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the UNG1 gene: The UNG1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
uracil DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair, AP site formation via deaminated base removal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uracil-DNA glycosylase
NP_013691.1
  • Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    229734..230813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182379.1NP_013691.1  TPA: uracil-DNA glycosylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12887
    Conserved Domains (1) summary
    COG0692
    Location:100337
    Ung; Uracil DNA glycosylase [Replication, recombination and repair]
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