U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NSE5 Smc5-Smc6 complex subunit NSE5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854985, updated on 6-Jul-2026
Official Symbol
NSE5
Official Full Name
Smc5-Smc6 complex subunit NSE5
Primary source
SGD:S000004485
Locus tag
YML023C
See related
AllianceGenome:SGD:S000004485; FungiDB:YML023C; VEuPathDB:YML023C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase inhibitor activity. Contributes to SUMO transferase activity. Involved in DNA repair. Located in nucleus. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See NSE5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (226994..228664, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein uL4m YML6 Neighboring gene 40S ribosomal protein eS17 RPS17A Neighboring gene adenine phosphoribosyltransferase APT1 Neighboring gene uracil-DNA glycosylase

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Anaphase onset before complete DNA replication with intact checkpoint responses. Torres-Rosell J, et al. Science, 2007 Mar 9. PMID 17347440
  2. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Yu Y, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35648833, Free PMC Article
  3. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. Taschner M, et al. EMBO J, 2021 Aug 2. PMID 34191293, Free PMC Article
  4. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Hallett ST, et al. Nucleic Acids Res, 2021 May 7. PMID 33849072, Free PMC Article
  5. Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Li S, et al. Proc Natl Acad Sci U S A, 2023 Nov 7. PMID 37903273, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
  2. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
  3. Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
    Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin looping NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair via homologous recombination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of telomere maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Smc5-Smc6 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Smc5-Smc6 complex subunit NSE5
NP_013689.1
  • Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    226994..228664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182381.1 → NP_013689.1  Smc5-Smc6 complex subunit NSE5

    See identical proteins and their annotated locations for NP_013689.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZF1, Q03718
    UniProtKB/TrEMBL
    B3LLM9
    Conserved Domains (1) summary
    pfam08691
    Location:1 → 517
    Nse5; DNA repair proteins Nse5 and Nse6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03718.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools