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TSA1 thioredoxin peroxidase TSA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854980, updated on 5-Jun-2017
Gene symbol
TSA1
Gene description
thioredoxin peroxidase TSA1
Primary source
SGD:S000004490
Locus tag
YML028W
Gene type
protein coding
RNA name
thioredoxin peroxidase TSA1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TPX1; ZRG14
See TSA1 in Map Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (220138..220728)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rcf1p Neighboring gene Usa1p Neighboring gene Yox1p Neighboring gene ribosomal 40S subunit protein S18B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA protection IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
polysome IDA
Inferred from Direct Assay
more info
PubMed 
Names
thioredoxin peroxidase TSA1
NP_013684.1
  • Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    220138..220728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182386.1NP_013684.1  TPA: thioredoxin peroxidase TSA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013684.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34760
    Conserved Domains (2) summary
    COG0450
    Location:1193
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:5176
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
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