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SRC1 Src1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854974, updated on 5-Jul-2025
Official Symbol
SRC1
Official Full Name
Src1p
Primary source
SGD:S000004497
Locus tag
YML034W
See related
AllianceGenome:SGD:S000004497; FungiDB:YML034W; VEuPathDB:YML034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HEH1; YML033W
Summary
Predicted to enable chromatin binding activity. Involved in establishment of mitotic sister chromatid cohesion; maintenance of rDNA; and mitotic sister chromatid segregation. Located in nuclear envelope. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SRC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (209525..212155)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cgi121p Neighboring gene AMP deaminase Neighboring gene recombinase RAD52 Neighboring gene Ndc1p

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Rodríguez-Navarro S, et al. Yeast, 2002 Jan 15. PMID 11754482
  2. Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Lokareddy RK, et al. Structure, 2015 Jul 7. PMID 26051712, Free PMC Article
  3. Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Webster BM, et al. Cell, 2014 Oct 9. PMID 25303532, Free PMC Article
  4. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
  5. Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism. Poon BP, et al. Front Genet, 2012. PMID 22876257, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
    Title: ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
  2. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
    Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
  3. Heh2 and Src1/Heh1 contain bipartite import sequences that associate intimately with the minor nuclear localization sequence-binding pocket of yeast importin alpha.
    Title: Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
  4. Heh1p has a role in the assembly or stability of the nuclear pore complexes, potentially through the formation of a lumenal bridge with Pom152p.
    Title: Lumenal interactions in nuclear pore complex assembly and stability.
  5. The inner nuclear membrane protein Src1 functions at the interface between subtelomeric gene expression and TREX-dependent messenger RNA export through the nuclear pore complexes.
    Title: The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of rDNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery HDA PubMed 
is_active_in nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Src1p
NP_013679.1
  • Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    209525..212155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182391.1 → NP_013679.1  TPA: Src1p

    See identical proteins and their annotated locations for NP_013679.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZE1, Q03707, Q03712
    UniProtKB/TrEMBL
    A6ZM29, B3LLL9, C7GT63
    Conserved Domains (2) summary
    cd12935
    Location:14 → 48
    LEM_like; LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins
    pfam09402
    Location:464 → 820
    MSC; Man1-Src1p-C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03707.2

Gene LinkOut

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