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AMD1 AMP deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854973, updated on 11-Aug-2022

Summary

Gene symbol
AMD1
Gene description
AMP deaminase
Primary source
SGD:S000004498
Locus tag
YML035C
See related
AllianceGenome:SGD:S000004498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AMD3
Summary
Enables AMP deaminase activity. Involved in guanine salvage and purine nucleotide metabolic process. Located in cytoplasm. Used to study pontocerebellar hypoplasia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2) and AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See AMD1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (206428..208860, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cgi121p Neighboring gene Src1p Neighboring gene recombinase RAD52

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the AMD1 gene: The AMD1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables AMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMP deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables AMP deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in guanine salvage IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in guanine salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in purine nucleotide metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in purine nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purine ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AMP deaminase
NP_013677.1
  • AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    206428..208860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182392.1NP_013677.1  TPA: AMP deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013677.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZE0, P15274
    UniProtKB/TrEMBL
    A0A0L8VKC3, A0A6A5PUQ7, A0A6C1DWP4, A0A816AG61, A6ZM28, B3LLL8, C7GT64, N1NZ21
    Conserved Domains (1) summary
    cd01319
    Location:299794
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.