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CGI121 Cgi121p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854972, updated on 18-Sep-2024

Summary

Official Symbol
CGI121
Official Full Name
Cgi121p
Primary source
SGD:S000004500
Locus tag
YML036W
See related
AllianceGenome:SGD:S000004500; FungiDB:YML036W; VEuPathDB:YML036W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in positive regulation of transcription by RNA polymerase II; regulation of cell aging; and telomere maintenance via recombination. Part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CGI121 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (205642..206293)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ymd8p Neighboring gene Lft1p Neighboring gene AMP deaminase Neighboring gene Src1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA threonylcarbamoyladenosine modification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in telomere maintenance via recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of EKC/KEOPS complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cgi121p
NP_013676.2
  • Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; ortholog of human TPRKB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    205642..206293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182394.1NP_013676.2  TPA: Cgi121p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013676.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBM6, D6VZD9, Q03705, Q6Q5A2
    UniProtKB/TrEMBL
    C7GT65, C8ZEG9
    Conserved Domains (1) summary
    pfam08617
    Location:19179
    CGI-121; Kinase binding protein CGI-121