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Klf15 Kruppel-like factor 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85497, updated on 12-Jan-2022

Summary

Official Symbol
Klf15provided by RGD
Official Full Name
Kruppel-like factor 15provided by RGD
Primary source
RGD:70918
See related
Ensembl:ENSRNOG00000017808
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nuclear speck. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 109.6), Liver (RPKM 91.5) and 9 other tissues See more
Orthologs
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Genomic context

See Klf15 in Genome Data Viewer
Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122965718..122978403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122364688..122377690)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene solute carrier family 41, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC108619

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular visceral epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to insulin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053536.2NP_445988.2  Krueppel-like factor 15

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000148
    Related
    ENSRNOP00000024011.2, ENSRNOT00000024011.6
    Conserved Domains (3) summary
    COG5189
    Location:318400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3320
    KLF15_N; N-terminal domain of Kruppel-like factor 15

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    122965718..122978403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236882.4XP_006236944.1  Krueppel-like factor 15 isoform X1

    See identical proteins and their annotated locations for XP_006236944.1

    UniProtKB/TrEMBL
    Q5FVT6
    Conserved Domains (3) summary
    COG5189
    Location:318400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3320
    KLF15_N; N-terminal domain of Kruppel-like factor 15
  2. XM_017592934.2XP_017448423.1  Krueppel-like factor 15 isoform X1

    UniProtKB/TrEMBL
    Q5FVT6
    Conserved Domains (3) summary
    COG5189
    Location:318400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3320
    KLF15_N; N-terminal domain of Kruppel-like factor 15
  3. XM_039108490.1XP_038964418.1  Krueppel-like factor 15 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:318400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3320
    KLF15_N; N-terminal domain of Kruppel-like factor 15
  4. XM_006236884.4XP_006236946.1  Krueppel-like factor 15 isoform X1

    See identical proteins and their annotated locations for XP_006236946.1

    UniProtKB/TrEMBL
    Q5FVT6
    Conserved Domains (3) summary
    COG5189
    Location:318400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3320
    KLF15_N; N-terminal domain of Kruppel-like factor 15
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