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AIM32 Aim32p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854955, updated on 3-Jun-2026
Official Symbol
AIM32
Official Full Name
Aim32p
Primary source
SGD:S000004514
Locus tag
YML050W
See related
AllianceGenome:SGD:S000004514; FungiDB:YML050W; VEuPathDB:YML050W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Acts upstream of or within cell redox homeostasis and protein-containing complex assembly. Located in mitochondrial intermembrane space and mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See AIM32 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (173139..174074)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sur7p Neighboring gene transcription regulator GAL80 Neighboring gene U2 snRNP complex subunit RSE1 Neighboring gene Gsf2p

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Apd1 and Aim32 Are Prototypes of Bishistidinyl-Coordinated Non-Rieske [2Fe-2S] Proteins. Stegmaier K, et al. J Am Chem Soc, 2019 Apr 10. PMID 30879301
  2. The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth. Lalève A, et al. Redox Biol, 2016 Apr. PMID 26629948, Free PMC Article
  3. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control. Zhang D, et al. J Biol Chem, 2021 Oct. PMID 34461091, Free PMC Article
  4. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast. Hansen KG, et al. Science, 2018 Sep 14. PMID 30213914
  5. The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. Brown CR, et al. J Biol Chem, 2010 Jul 23. PMID 20457600, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control.
    Title: Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Aim32p
NP_013662.1
  • 2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    173139..174074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182408.1 → NP_013662.1  Aim32p

    See identical proteins and their annotated locations for NP_013662.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZM17, B3LLK7, B5VP80, C7GS66, C8ZEF8, D6VZC5, Q04689
    UniProtKB/TrEMBL
    G2WK07, N1P692
    Conserved Domains (1) summary
    pfam06999
    Location:60 → 306
    Suc_Fer-like; Sucrase/ferredoxin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04689.1

Gene LinkOut

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