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OGG1 8-oxoguanine glycosylase OGG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854942, updated on 2-Nov-2024

Summary

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Official Symbol
OGG1
Official Full Name
8-oxoguanine glycosylase OGG1
Primary source
SGD:S000004525
Locus tag
YML060W
See related
AllianceGenome:SGD:S000004525; FungiDB:YML060W; VEuPathDB:YML060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in base-excision repair, AP site formation; error-free translesion synthesis; and telomere maintenance via telomerase. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OGG1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (151871..153001)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mft1p Neighboring gene DNA helicase PIF1 Neighboring gene lysophospholipase Neighboring gene Hug1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. van der Kemp PA, et al. Proc Natl Acad Sci U S A, 1996 May 28. PMID 8643552, Free PMC Article
  2. Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals. Karahalil B, et al. Nucleic Acids Res, 1998 Mar 1. PMID 9469830, Free PMC Article
  3. Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi. Furtado C, et al. PLoS One, 2012. PMID 22876325, Free PMC Article
  4. Opposite base-dependent excision of 7,8-dihydro-8-oxoadenine by the Ogg1 protein of Saccharomyces cerevisiae. Girard PM, et al. Carcinogenesis, 1998 Jul. PMID 9683192
  5. The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Sandigursky M, et al. Nucleic Acids Res, 1997 Nov 15. PMID 9358166, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Saccharomyces cerevisiae ablation of Ogg1p leads to an increase in oxidized guanine level in telomeric DNA.
    Title: Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast.
  2. Ogg1 prevents poly(GT) tract instability in the mitochondrial genome
    Title: Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.
  3. The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.
    Title: Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidized base lesion DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair, AP site formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair, AP site formation IEA
Inferred from Electronic Annotation
more info
  
involved_in error-free translesion synthesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
8-oxoguanine glycosylase OGG1
NP_013651.1
  • Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    151871..153001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182419.1 → NP_013651.1  TPA: 8-oxoguanine glycosylase OGG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013651.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZB3, P53397
    UniProtKB/TrEMBL
    B3LLJ5, C7GVZ6, C8ZEE5, G2WJZ5, N1NYZ7
    Conserved Domains (1) summary
    TIGR00588
    Location:1 → 328
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53397.1

Gene LinkOut

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